SepsisDataNet.NRW

Conditions

A41

Madita Mühlhaus, Birte Dyck, Andrea Witowski, Matthias Unterberg, Alexander Wolf et al. (32 authors)

Critical Care2026-05-30

10.1186/s13054-026-06115-5

Human Cytomegalovirus Serostatus Defines Cytokine-Based Predictive Signatures in Sepsis

Frederik Krause, Birte Dyck, K Käppler, Matthias Unterberg, Patrick Thon et al. (27 authors)

Pathogens2026-01-24

10.3390/pathogens15020129

AIMing for survival: The impact of the free and total AIM concentration in septic patients.

Dyck B, Bosch Dos Santos U, Müller C, Nowak H, Rahmel T, Palmowski L, Unterberg M, Wolf A, von Busch A, Witowski A, Westhus B, Sitek B, Rump K, Putensen C, Ehrentraut SF, Zarbock A, Henzler D, Babel N, Eisenacher M, Marcus K, Ellger B, Koos B, Adamzik M, Ziehe D, Bergmann L.

2025-11-04

10.3389/fimmu.2025.1685119

Employing artificial intelligence for optimising antibiotic dosages in sepsis on intensive care unit: a study protocol for a prospective observational study (KI.SEP)

Britta Marko, Lars Palmowski, Hartmuth Nowak, Andrea Witowski, Björn Koos et al. (13 authors)

BMJ Open2024-12-014 citations

10.1136/bmjopen-2024-086094

Interventions

Group 1: Septic patients following the sepsis-3 definition are included in the study within 24 hours after diagnosis. Subsequently, 75 ml of whole blood, urine samples and BAL are sampled. The blood i

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Study arm 1: • Fulfillment of the current "sepsis” definition (01.04.2019: Sepsis3 guideline) • Presence of consent Study arm 2: • Non-compliance with the current "sepsis" definition (01.04.2019: Sepsis3 guideline) Elective operated patients with surgical interventions with severe or moderate surgical risk • Presence of consent

Exclusion criteria

Exclusion criteria: Study arm 1: • Non-existent consent to participate in the study • Previous participation in the study Non-compliance with the current "sepsis" definition (01.04.2019: Sepsis3 guideline) • HB <8 Study arm 2: • Non-existent consent to participate in the study • Previous participation in the study Fulfillment of the current "sepsis" definition (01.04.2019: Sepsis3 guideline) • HB <8

Design outcomes

Primary

Measure	Time frame
The survival of the patients is observed over a period of at least 30 days.	—

Secondary

Measure	Time frame
Clinical and molecular data	—

Countries

Germany

Contacts

Public ContactAlexander von Busch

Universitätsklinikum Knappschaftskrankenhaus Bochum

alexander.von-busch@kk-bochum.de023429983000

Outcome results

None listed