Analysis of the pulmonary microbiome in patients with respiratory failure

Analysis of the pulmonary microbiome in patients with respiratory failure - PULMONARY-Trial (pulmonary microbiome analytic in patients with respiratory failure - Trial)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00018799

Enrollment

Registered

2019-11-18

Start date

2019-12-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41.9 J80.01

Interventions

Group 1: Analysis of the micorbiom via Next Generation Sequencing of lung secretion directly after onset and intubation in 50 ventilated ARDS patients. Group 2: Analysis of the micorbiom via Next Gene

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers Included are lung healthy volunteers who, in the period under investigation a thoracoabdominal oesophageal resection and the procedure is performed of this study. A total of 10 lung healthy volunteers are expected to be enrolled in the study will be included. Inclusion takes place in chronological order. The following must be included the following criteria must be met: - written declaration of consent by the study participant - Age >18 years - no acute or chronic inflammatory lung disease Patients with acute respiratory failure This includes all patients who have to be intubated and ventilated at the Surgical Clinic of Heidelberg University Hospital due to acute respiratory failure during the examination period. A total of 50 patients will be included in the study. Inclusion will take place in chronological order. The following criteria must be fulfilled: - Acute respiratory failure - Invasive ventilation via endotracheal tube or tracheostoma - written declaration of consent by the study participant or his legally appointed representative - Age >18 years

Exclusion criteria

Exclusion criteria: - Refusal to participate in the study - pregnancy - Age <18 years

Design outcomes

Primary

Measure	Time frame
Examination of pulmonary microbiome in ARDS (directly after onset and intubation) compared to lung healthy patients by Next Generation Sequencing	—

Secondary

Measure	Time frame
- Investigation of changes in the microbiome in correlation with clinically relevant complications. - Evaluation of the prognostic significance of microbial analysis. - Correlation between pathogen diagnosis via NGS (Next Generation Sequencing) and culture based.	—

Countries

Germany

Contacts

Public ContactFelix Schmitt

Klinik für Anästhesiologie, Universitätsklinikum Heidelberg

felix.schmitt@med.uni-heidelberg.de00 49 6221 56 39421

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026