This study recruits healthy participants.
Conditions
Interventions
Group 1: Combined oral contraceptive pill (oestrogen: ethinylestradiol
gestagen: non-methylated testosterone derivate, e.g. dienogest), intake: 21 days + 7 days break)
Study protocol: maximal strength test, followed by a single exercise intervention with 4 sets at 10 repetitions back squat each
Collection of blood samples at 4 time points (fasted, before and after exercise, as well as 24 hours later)
Explosive strength test (fasted, before and after exercise, as well as 24 hours later)
Timing of testing: during the 7-day break
Group 2: Natural cycle
Timing of testing: between day 1 and 7 of the menstrual cycle
Sponsors
Abteilung Molekulare und Zelluläre Sportmedizin, Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 2-3 sessions of strength training per week
Exclusion criteria
Exclusion criteria: amenorrhoea; pregnancy in the preceding 12 months; use of other hormone-containing medication (e.g. L-thyroxin, IUD, hormone patches); use of emergency contraceptives in the preceding 6 months; more than 2 sessions endurance training per week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in hormone concentrations of testosterone, estradiol and cortisol; Method: collection of blood samples at 4 time points (fasted, before and after exercise, as well as 24 hours later). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in serum concentrations of markers of the tryptophan metabolism (tryptophan and kynurenin), Method: collection of blood samples at 4 time points (fasted, before and after exercise, as well as 24 hours later); 2. Neuromuscular fatigue, Method: explosive strength test (fasted, before and after exercise, as well as 24 hours later); 3. Blood lactate levels, Method: collection of capillary blood at 3 time points (rested, before and after exercise) | — |
Countries
Germany
Contacts
Public ContactLisa Umlauff
Abteilung Molekulare und Zelluläre Sportmedizin, Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln
Outcome results
None listed