Indicated prevention of mental disorders in subjects with initial panic symptomatology: effectiveness and underlying mechanisms of action

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00018077

Enrollment

300

Registered

2019-08-29

Start date

2018-09-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F00-F99

Interventions

Group 1: Intervention group: Participation in preventive program. Intervention delivered individually in person: one workshop (3 hours) and one booster session (30 min) spaced 2 weeks apart. During th

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Healthy adults reporting a fearful spell / panic attack during the past 12 months

Exclusion criteria

Exclusion criteria: - current treatment (intention) due to psychological problems - meeting criteria for any 12-month mental disorder, 12-month psychotic or bipolar I disorder, acute suicidality - severe physical disease (respiratory, cardiac or neurologic disease, epilepsy).

Design outcomes

Primary

Measure	Time frame
Intervention efficacy: Reduction of panic severity from baseline to post-assessment (PD-D, PDSS-SR) Prevention efficacy: Incidence rates for any full-threshold mental disorder from entry exam to 12-month follow-up assessment (DSM-5 CIDI)	—

Secondary

Measure	Time frame
Intervention efficacy: Other symptom changes from baseline to post-assessment (BSQ, PAI, ASI, MI, CLQ, DSM-5 CCSM), other clinical changes from baseline to post-assessment (e.g. levels of impairment and disability, DSM-5 CIDI) Prevention efficacy: Incidence and recurrence rates for individual sub-threshold and full-threshold mental disorders from entry exam to follow-up assessment (DSM-5 CIDI), changes in panic severity from post- to follow-up assessment (PD-D, PDSS-SR); other symptom changes from post- to follow-up assessment (BSQ, PAI, ASI, MI, CLQ, DSM-5 CCSM); other clinical changes from post- to follow-up assessment (e.g. levels of impairment and disability, DSM-5 CIDI) Mediator variables: Changes in defensive responsivity to acute threat and potential harm, indicated by different indices of defensive mobilization as derived from experimental paradigms from baseline to post-assessment and post- to follow-up assessment as well as from baseline- to follow-up assessment.	—

Measure

Time frame

Intervention efficacy: Other symptom changes from baseline to post-assessment (BSQ, PAI, ASI, MI, CLQ, DSM-5 CCSM), other clinical changes from baseline to post-assessment (e.g. levels of impairment and disability, DSM-5 CIDI) Prevention efficacy: Incidence and recurrence rates for individual sub-threshold and full-threshold mental disorders from entry exam to follow-up assessment (DSM-5 CIDI), changes in panic severity from post- to follow-up assessment (PD-D, PDSS-SR); other symptom changes from post- to follow-up assessment (BSQ, PAI, ASI, MI, CLQ, DSM-5 CCSM); other clinical changes from post- to follow-up assessment (e.g. levels of impairment and disability, DSM-5 CIDI) Mediator variables: Changes in defensive responsivity to acute threat and potential harm, indicated by different indices of defensive mobilization as derived from experimental paradigms from baseline to post-assessment and post- to follow-up assessment as well as from baseline- to follow-up assessment.

—

Countries

Germany

Contacts

Public ContactSabrina Wideburg

Technische Universität Dresden, Institut für Klinische Psychologie und Psychotherapie, Behaviorale Epidemiologie

sabrina.wideburg@tu-dresden.de+49-351-463-39421

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026