The influence of probiotics on the salivary microflora and their Integration into in situ dental biofilm

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00017822

Enrollment

Registered

2019-09-05

Start date

2011-04-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Voluntary healthy volunteers

Interventions

Group 1: Intake of probiotic products during 28 days - Enterococcus faecalis (SYM) Symbioflor 1 (SymbioPharm GmbH, Herborn, Germany) 3x daily 30 drops (5x 50ml bottles) Group 2: Lactobacillus casei

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: low caries incidence (DMFT 0-5)

Exclusion criteria

Exclusion criteria: Intake of antibiotics during the last 6 months Intake of probiotics during the last 6 months Periodontitis or caries lesions

Design outcomes

Primary

Measure	Time frame
Detection of probiotics supplied in biofilm and saliva V1-V3 = Screening (S) V4,V5 = Intervention (I) V6-V8 = Wash out (WO)	—

Countries

Germany

Contacts

Public ContactNicole Arweiler

Klinik für Parodontologie und peri-implantäre Erkrankungen

arweiler@med.uni-marburg.de06421 5863235

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026