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Treatment of peri-implant mucositis with repeated application of chlorhexidine chips or gel during supportive therapy – a randomized clinical trial

Treatment of peri-implant mucositis with repeated application of chlorhexidine chips or gel during supportive therapy – a randomized clinical trial - peri-implant mucositis study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00017782
Enrollment
40
Registered
2019-12-17
Start date
2015-09-28
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M27.62 (ICD 10 CM) Post-osseointegration biological failure of dental implant

Interventions

Group 1: IIT In peri-implant sites with mucositis CHX (chlorhexidine) gel is applied in the control group (GC) at baseline and after three months. At baseline and after six months, peri-implant pocket

Sponsors

Clinic of Preventive Dentistry, Periodontology and Cariology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 110 Years

Inclusion criteria

Inclusion criteria: • Adult women and men (=18 y) • Informed consent as documented by signature • Systemically healthy subjects • At least one dental implant loaded by fixed single crowns or bridges (screwed or cemented) with mucositis in terms of a probing pocket depth between 3 an 5 and bleeding on probing • Bone loss = 2mm as detectable on X-ray • Ability to read and understand the patient information

Exclusion criteria

Exclusion criteria: • Patients with active periodontal pockets • Pregnant or nursing women or women planning to have a child • Patients with antibiotic therapy within the previous 6 months • Patients with peri-implantitis therapy within the previous 3 months • Subjects with an allergy to CHX • Heavy smokers (=10 cigarettes per day) • Anti-coagulated patients (exception: =100 mg/d acetylsalicylic acid) • Removable prostheses attached on the affected implants

Design outcomes

Primary

MeasureTime frame
Manual assessment of peri-implant pocket depths with a periodontal probe after 6 months

Secondary

MeasureTime frame
Assessemnt of bleeding-on-probing and aMMP-8 levels after 6 months

Countries

Switzerland

Contacts

Public ContactPatrick Schmidlin

Zentrum für ZahnmedizinUniversität Zürich

patrick.schmidlin@zzm.uzh.ch0041446343284

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026