Evaluation of the Jaw Index for the determination of micrognathia and visualization of the facial profile using 3D photography in healthy newborns and infants with Pierre Robin sequence and their first-degree relatives

Evaluation of the Jaw Index for the determination of micrognathia and visualization of the facial profile using 3D photography in healthy newborns and infants with Pierre Robin sequence and their first-degree relatives - Jaw Index 3.4

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00017769

Enrollment

Registered

2020-05-18

Start date

2018-04-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MedDRA - 10035009 Q87.0

Interventions

Group 1: Determination of Jaw Index and MacLean values as well as two 3D-photographs at the same day in children with Pierre Robin Sequence. Group 2: Determination of Jaw Index and MacLean values as w

Eligibility

Sex/Gender

All

Age

No minimum to 6 Months

Inclusion criteria

Inclusion criteria: RS Infants: Infants with RS (based on the clinical diagnostic criteria: retrognathia, glossoptosis and obstructive breathing) Control group: Full-term newborns > 37 0/7 weeks of gestational age 1st degree relatives for photos (parents): parents, first degree siblings of both study groups

Exclusion criteria

Exclusion criteria: Childhood malformations or chromosomal abnormalities in the healthy control group

Design outcomes

Primary

Measure	Time frame
The Jaw Index differs significantly between healthy newborns and infants with Pierre Robin sequence.	—

Secondary

Measure	Time frame
1. the Jaw Index is well reproducible and shows no relevant difference between repeat measurements of one examiner or between two different examiners 2. the measured values of alveolar overbite differ depending on the waking state or muscle tone (e.g. during sleep or awake). 3. the lower jaw of children with RS shows a catch-up growth after spur plate treatment, thus the Jaw-Index decreases in the course of plate therapy. 4. the facial profile in the 3D image in healthy children differs significantly from that in children with RS. 5. The facial profile in the 3D image of children with RS is changed after Tuebingen plate treatment, the lower jaw shows catch-up growth and the degree of retrognathy decreases in the course of therapy. 6. The orthodontic history and clinical measurement of jaw dimensions using Jaw Index and 2D/3D photography in adult parents of a PRS child differ from those of the healthy control group.	—

Measure

Time frame

1. the Jaw Index is well reproducible and shows no relevant difference between repeat measurements of one examiner or between two different examiners 2. the measured values of alveolar overbite differ depending on the waking state or muscle tone (e.g. during sleep or awake). 3. the lower jaw of children with RS shows a catch-up growth after spur plate treatment, thus the Jaw-Index decreases in the course of plate therapy. 4. the facial profile in the 3D image in healthy children differs significantly from that in children with RS. 5. The facial profile in the 3D image of children with RS is changed after Tuebingen plate treatment, the lower jaw shows catch-up growth and the degree of retrognathy decreases in the course of therapy. 6. The orthodontic history and clinical measurement of jaw dimensions using Jaw Index and 2D/3D photography in adult parents of a PRS child differ from those of the healthy control group.

—

Countries

Germany

Contacts

Public ContactCornelia Wiechers

Klinik für Kinder- und Jugendmedizin Abteilung Neonatologie

Cornelia.Wiechers@med.uni-tuebingen.de07071-2962310

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026