G20 G25.0 G50.1 G52.2
Conditions
Interventions
Group 1: As the study-specific intervention, up to four sessions are performed on days 0-4 during hospitalisation. Duration approx. 30-90 minutes each.
Day 0 or 1: After the patient has recovered su
Sponsors
Universitätsklinikum FreiburgAbteilung für Stereotaktische und Funktionelle Neurochirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patients of at least 35 years of age and max. 65 years; 2. Patients with one of the following diagnoses: a) essential tremor; b) tremor-dominant Parkinson's disease with thalamic target; c) drug therapy-refractory Parkinson's disease with effect fluctuations, DBS target in the subthalamic nucleus (STN); d) neuropathic pain; 3. Patients for whom according to DGN guidelines (www.dgn.org) the indication for conventional DBS surgery exists and in whom the stimulation electrodes regularly run through the pathways of the medial lemniscus or in its immediate vicinity; 4. Written, informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with symptoms of dementia; 2. patients with signs of cerebral atrophy; 3. patients with immunodeficiency or under immunosuppressants; 4. pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To demonstrate in an explorative proof-of-concept approach that it is possible to feed information-bearing signals along the medial lemniscus fiber system for conscious interpretation by the patient, operationalized as the patient's performance in correctly recognizing and allocating the perceived signals (in %). | — |
Secondary
| Measure | Time frame |
|---|---|
| - To examine and describe the stimulation parameters and the interactions of these parameters with stimulation success of these fiber systems depending on the angle between electrode and fiber. - To carry out a qualitative characterization of the types of information that the patient can use. - To study the learning speed, robustness and reliability of the conscious signal interpretation by the patient(s). | — |
Countries
Germany
Contacts
Public ContactBastian Sajonz
Universitätsklinikum FreiburgAbteilung für Stereotaktische und Funktionelle Neurochirurgie
Outcome results
None listed