Impact of the intraoperative hemodynamic management on ischemia-sensitive tissues

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00017735

Enrollment

Registered

2019-08-07

Start date

2019-08-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

5-885 (OPS) Autologous breast reconstruction C50 N17.9

Interventions

Group 1: Intraoperative hemodynamic regime LFA = liberal fluid vasopressor-restrictive administration (Anker AM et al., 2018, Clin Hemorheol Microcirc.). Group 2: Intraoperative hemodynamic regime FRV

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients undergoing uni- or bilateral, primary or secondary DIEP flap autologous breast reconstruction are considered eligible for inclusion.

Exclusion criteria

Exclusion criteria: Increased preoperative serum creatinine levels or known kidney injury, congestive heart failure

Design outcomes

Primary

Measure	Time frame
Analysis of highly sensitive kidney-specific urine parameters (TIMP-2 and IGFBP-7) via ELISA. Urine samples are taken pre-, intra- and postoperatively.	—

Secondary

Measure	Time frame
Blood tests (analysis of serum creatinine levels and blood urea nitrogen); urine output; DIEP flap perfusion; renal replacement therapy; hospitalization;	—

Countries

Germany

Contacts

Public ContactAlexandra Anker

Universitätsklinikum Regensburg

alexandra.anker@ukr.de0941 944 6763

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026