F50.0
Conditions
Interventions
Group 1: Anorexia nervosa patients receive a daily dose (1 sacket that is 3000mg) of a freely available multi-strain probioticum (Lactobacilli and Bifidobacteria) for 6 months.
Group 2: Anorexia nervo
Sponsors
Medical University of Vienna, Department of Child and Adolescent Psychiatry, Eating Disorder Unit
Eligibility
Sex/Gender
All
Age
13 Years to 19 Years
Inclusion criteria
Inclusion criteria: 1. Female and male patients >=13 and <20 2. Written Informed consent. 3. Patient with typical and atypical anorexia nervosa according to DSM-5 4. Healthy control subjects without current psychiatric disorder according to ICD-10 and without eating disorders in the past.
Exclusion criteria
Exclusion criteria: 1. Organic brain disease 2. psychotic disorder 3. bipolar disorder 4. substance use disorder 5. insufficient knowledge of German language 6. Organic disorder with influence on gastrointestinal tract for example diabetes or inflammtory bowel diseases 7. antibiotic use during the previous 6 weeks. 8. pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Approximation of microbiome (MI) composition after probiotica administration to that of heathly normal-weight age-matched controls which in consequence leads an increase in body weight as measured in body mass index. Measurement times are 6 and 12 months after inclusion in the study. Assessments include psychological tests, pathopsychological questionnaires, blood-samples, stool-samples and functional MRI at each measurement time. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondarily, an improvement in gastrointestinal discomfort, a reduction in depressive symptoms and a reduction in inflammatory processes and intestinal permeability may be associated with these MI changes. Measurement times are 6 and 12 months after inclusion in the study. Assessments include psychological tests, pathopsychological questionnaires, blood-samples, stool-samples and functional MRI at each measurement time. | — |
Countries
Austria
Contacts
Public ContactAndreas Karwautz
Medical University of Vienna, Department of Child and Adolescent Psychiatry, Eating Disorder Unit
Outcome results
None listed