Regulation of the Kynurenine pathway in response to acute exercise
Conditions
Interventions
Group 1: an acute bout of high-intensity interval exercise
Group 2: an acute bout of moderate continuous exercise
Sponsors
Deutsche Sporthochschule KölnInstitut für Kreislaufforschung und SportmedizinAbt. molekulare und zelluläre Sportmedizin
Eligibility
Sex/Gender
Male
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: In this study, healthy recreational runners between the ages of 18 – 35 years old will be recruited. Healthy will be classified as a BMI<30. This will be defined when measuring body composition via bio electrical impedance. Recreational runners will be classified as between 2-5hr of running per week.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they have had any previous history of a muscle disorder, cardiac or kidney disease or medication (anti-inflammatory drugs, antibiotics and supplements). All participants will complete a questionnaire about their medical history and training status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is to investigate the effect of exercise intensity on measurements of Tryptophan and Kynurenine. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome of this study is to investigate the time course changes in Tryptophan and Kynureine one hour post exercise, as well as further pathway metabolites (kynurenic acid, quinolinic acid) and enzyme expression (IDO1, KAT4, KMO) measured in PBMCs. | — |
Countries
Germany
Contacts
Public ContactAlan Metcalfe
Deutsche Sporthochschule KölnInstitut für Kreislaufforschung und SportmedizinAbt. molekulare und zelluläre Sportmedizin
Outcome results
None listed