Healthy subjects
Conditions
Interventions
Group 1: Non-alkalized cocoa
Group 2: Alcalized cocoa
Sponsors
Institut Danone Ernährung für Gesundheit e.V.; Forschungsförderung 2009;
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Nonsmoker, written informed consent
Exclusion criteria
Exclusion criteria: Regular supplementation of vitamin C, vitamin E and phytochemicals (e.g., tea or red wine extract), cow’s milk allergy, lactose intolerance, diseases of the liver, the kidneys and the gastrointestinal tract, metabolic disorders (e.g., dyslipidemia, diabetes mellitus), eating disorders (anorexia nervosa, bulimia nervosa), pregnancy, lactation, drug abuse (narcotic and further psychotropic drugs), participation in another trial simultaneously or in the previous 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma appearance of (+)-catechin, (–)-catechin and epicatechin; Plasma concentrations before and 0.5, 1.0, 1.5, 2.0, 3.0 and 6.0 h after consumption. | — |
Secondary
| Measure | Time frame |
|---|---|
| Antioxidants (vitamin C, E, beta-carotene, uric acid), antioxidant capacity (TEAC), oxidative stress (peroxides, oxidized LDL, 8-hydroxy-2’deoxy-guanosin), insulin, lipids (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides), blood pressure; Concentrations in serum/plasma before and 0.5, 1.0, 1.5, 2.0, 3.0 and 6.0 h after consumption. | — |
Countries
Germany
Contacts
Public ContactAndreas Reusch
Institut für Ernährungs- und Lebensmittelwissenschaften, Abt. Ernährungsphysiologie Universität Bonn
Outcome results
None listed