Ventilator induced lung injury
Conditions
Interventions
Group 1: Long operative procedures > 4 hours.
Analysis of the composition of exhaled air intraoperatively in 5-minute intervals.
Group 2: One-lung Ventilation.
Analysis of the composition of exhaled a
Sponsors
Universtitätsklinikum des Saarlandes, Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Patients undergoing elective surgery • Written consent of the patient • Age = 18 years • ASA I-III • No participation in another study (up to 30 days before inclusion in the study) • Total Intravenous Anesthesia (TIVA) with propofol and remifentanil • BMI = 35kg / m² • Inclusion criteria depending on the patient group: o Planned operating time> 4 hours o Planned surgery that requires one-lung ventilation o Planned laparoscopic surgery
Exclusion criteria
Exclusion criteria: • rejection by the patient • pre-existing conditions or patient circumstances that make a patient's examination impossible or meaningless (for example, dementia, psychiatric disorders, lack of speech or speaking skills) • ASA> III • drug abuse • Positive HIV or hepatitis test • Isolation of the patient • pregnancy • contraindications or known incompatibilities with intravenous narcotics used • contraindications for total intravenous anesthesia • Anesthesia guided by volatile anesthetics • BMI> 35kg / m²
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Influence of mechanical ventilation on the exhaled pentanal concentration | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the exhaled volatile organic compounds by mechanical ventilation | — |
Countries
Germany
Contacts
Public ContactLukas Müller-Wirtz
Universitätsklinikum des Saarlandes, Experimentelle Anästhesiologie, Center of Breath Research (CBR)
Outcome results
None listed