J80.0
Conditions
Interventions
Group 1: Assessment of the effect of prone positioning on end-exspiratory transpulmonary pressure when using different methods of PEEP (positive end-expiratory pressure) titration.
Sponsors
Universitätsmedizin Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Moderate to severe ARDS (acute respiratory distress syndrome) (PaO2/FiO2 < 200 mmHg), consent to the study
Exclusion criteria
Exclusion criteria: - mechanical ventilation for less than 12 hours or more than 5 days - severe head injury - inherited cardiac malformations - severe cardial valvular pathologies - presence of arrhythmias - immunosuppression - end-stage chronic organ failure - expected survival of less than 24 hours - pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| End-expiratory transpulmonary pressure in prone position when using different methods of PEEP titration. The respiratory mechanics are evaluated at the bedside as soon as the inclusion criteria are met. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung mechanics, intraabdominal pressure and hemodynamics in prone position when using different methods of PEEP titration. As soon as the inclusion criteria are met, respiratory mechanics, hemodynamic and other physiological parameters are measured. | — |
Countries
Germany
Contacts
Public ContactJoerg Krebs
Universitätsmedizin Mannheim
Outcome results
None listed