N18.5
Conditions
Interventions
Group 1: Hypervolemic HD patients (group H)
After first hemodialysis, a bioimpedance measurement is performed. Based on the result, a classification into a hypervolemic or normovolemic group will perf
Sponsors
Universitätsklinikum Halle, Klinik für Innere Klinik II, KfH Nierenzentrum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - age >18 years - endstage renal disease (treated with HD) for at least 3 months - HD ultrafiltration > 2000 ml per session after long dialysis-free interval
Exclusion criteria
Exclusion criteria: - lack of consent / lack of cooperation - known malignant tumor disease - acute infection (CRP> 50mg / l, fever, chills) - psychiatric or neurological disorders that affect the ability to consent - known pregnancy or lack of contraception (premenopausal women)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is defined to compare the amount of = 25% increase of CD16+ monocyte population in hypervolemic (group H) versus normovolemic (group N) HD patients between two hemodialysis sessions (long dialysis-free interval). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints should be investigated between the two groups H and N: - quantitative shift of monocyte subpopulations and decrease of myeloid suppressor cells - change in concentration of oxidative stress (MitoROS) - level of IL-1ß concentration - activation of exosomes | — |
Countries
Germany
Contacts
Public ContactAnnegret Wilke
Universitätsklinikum Halle, Klinik für Innere Medizin II, KfH Nierenzentrum Halle
Outcome results
None listed