In vitro measurements in pump systems for extracorporeal circulation with altered whole blood viscosity

In vitro measurements in pump systems for extracorporeal circulation with altered whole blood viscosity - INVEKZ-VISK

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00017402

Enrollment

Registered

2020-06-24

Start date

2020-07-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

basic research regarding hemolysis, anticoagulation, inflammation and pump settings in extracorporeal circulation

Interventions

Group 1: in vitro circuit with/without pulsatility

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: Age > 15 years and medically indicated blood withdrawal

Exclusion criteria

Exclusion criteria: blood volume below 300 ml

Design outcomes

Primary

Measure	Time frame
free hemoglobin after 6 hours (calculation of N.I.H. [Normalized Index of Hemolysis] and M.I.H. [Modified Index of Hemolysis])	—

Secondary

Measure	Time frame
- concentration of inflammatory proteins (e.g. TNF-alpha, IL1beta, IL-6, IL-8) after 6 hours - concentration of neutrophil elastase after 6 hours - von-Willebrand Factor (VWF) antigen, VWF-Multimere after 3 and 6 hours - analysis of thrombocyte function after 3 hours - Quick, pTT, Fibrinogen, Antithrombin III, Protein C and Protein S after 6 hours	—

Countries

Germany

Contacts

Public ContactGeorg Trummer

Universitätsherzzentrum Freiburg - Bad Krozingen, Klinik für Herz- und Gefäßchirurgie

georg.trummer@universitaets-herzzentrum.de076127088888

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026