Phase-contrast MRI: CSF- and spinal cord motion across the cervical spine

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00017351

Enrollment

220

Registered

2019-05-28

Start date

2019-06-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G91.2 G93.2 G96.0

Interventions

Group 1: healthy participants will be assessed by the following parameters - age - gender - weight/size - medication - pain according to the numeric rating scale - Karnofsky-Index and will recieve a

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: patients: diagnosed idiopathic intracranial hypotension and hypertension, normal pressure hydrocephalus

Exclusion criteria

Exclusion criteria: MRI-contraindications (pregnancy, non-MRI-conform implants, etc.), symptomatic chronic psychiatric or internal disease healthy participants: any neurological impairement or known neurological disease patients: chronic central nervous system disease symptomatic peripheral nervous system disease

Design outcomes

Primary

Measure	Time frame
Correlation of spinal cord movement to CSF-flow, each measured using the absolut displacement (=area under the curve) measured by phase-contrast MRI in respect to age and gender, statistically evaluated by multiple linear regression using SPSS at time of n=130 included healthy participants.	—

Secondary

Measure	Time frame
At time of completed data aquisition the following analysis will be conducted using SPSS; for correlation analysis mutliple regression, for group comparison Mann-Whithney-U-Test will be applied: a) Correlation of diastolic pressure to spinal cord movement in healthy controls b) Quantification of the influence of alterations in venous outflow restistance to alteration of spinal cord movement and CSF-flow in healthy controls c) Group comparison of spinal cord movements and CSF-flow: male vs. female, soubgroups divide by age (age 20-40, 41-60, 61-80) d) Age and sex-matched group comparison of patients and healthy controls: spinal cord movements and CSF-flow per cervical segmental level e) Descriptive quantitative means and standard diviation of spinal cord movements and CSF-flow across the cervical spinal (vertebra C2-C7) in healthy controls in subgroups devided by age and sex f) Relation of CSF-flow and spinal cord movements in patients to clinical impairement	—

Measure

Time frame

At time of completed data aquisition the following analysis will be conducted using SPSS; for correlation analysis mutliple regression, for group comparison Mann-Whithney-U-Test will be applied: a) Correlation of diastolic pressure to spinal cord movement in healthy controls b) Quantification of the influence of alterations in venous outflow restistance to alteration of spinal cord movement and CSF-flow in healthy controls c) Group comparison of spinal cord movements and CSF-flow: male vs. female, soubgroups divide by age (age 20-40, 41-60, 61-80) d) Age and sex-matched group comparison of patients and healthy controls: spinal cord movements and CSF-flow per cervical segmental level e) Descriptive quantitative means and standard diviation of spinal cord movements and CSF-flow across the cervical spinal (vertebra C2-C7) in healthy controls in subgroups devided by age and sex f) Relation of CSF-flow and spinal cord movements in patients to clinical impairement

—

Countries

Germany

Contacts

Public ContactKatharina Wolf

Universitätsklinik FreiburgKlinik für Neurologie und Neurophysiologie

katharina.wolf@uniklinik-freiburg.de004976127050010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 12, 2026