Neuronal Oscillations in Parkinson Disease and Essential Tremor

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00017327

Enrollment

Registered

2020-11-03

Start date

2021-04-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G25.0 G20.0

Interventions

Group 1: Deep brain stimulation of the ventral intermediate nucleus (VIM) or posterior subthalamic area (PSA) in essential tremor (ET) or the subthalamic nucleus (STN), internal globus pallidus (GPi)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients undergoing deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) or posterior subthalamic area (PSA) for treatment of essential tremor (ET) Patients undergoing DBS of the subthalamic nucleus (STN), internal globus pallidus (GPi) or VIM with medically refractory tremor-dominant Parkinson's disease (PD) Selection by multidisciplinary teams consisting of neurologists, psychiatrists and functional neurosurgeons Patients must be able to give consent

Exclusion criteria

Exclusion criteria: Cognitive impairment (judge by interdisciplinary team) Intracranial bleeding, confusion, severe CSF leak, infection or any other complication after first stage of surgery Patients with accompanying severe medical or psychiatric disorders will also be excluded

Design outcomes

Primary

Measure	Time frame
Identify spectral changes in the LFP during and before the onset of tremor. Local field potentials will be recorded from externalized DBS leads between stage 1 and stage 2 surgery (either 1 or 2 days after lead implantation). We will use a TMSi Porti amplifier and custom-written software to record the time series signal. At a later stage, the time series signal will be pre-processed (filtered, detrended) and analysed (time-frequency decomposition) to examine changes in the time-frequency spectrogram related to tremor.	—

Measure

Time frame

Identify spectral changes in the LFP during and before the onset of tremor. Local field potentials will be recorded from externalized DBS leads between stage 1 and stage 2 surgery (either 1 or 2 days after lead implantation). We will use a TMSi Porti amplifier and custom-written software to record the time series signal. At a later stage, the time series signal will be pre-processed (filtered, detrended) and analysed (time-frequency decomposition) to examine changes in the time-frequency spectrogram related to tremor.

—

Secondary

Measure	Time frame
Study the temporal dynamics of spectral changes related to tremor.	—

Countries

Germany

Contacts

Public ContactVeerle Visser-Vandewalle

Direktorin der Klinik für Stereotaxie und Funktionelle Neurochirurgie Universitätsklinikum Köln

veerle.visser-vandewalle@uk-koeln.de+49 221 478-82793

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026