Optimizing refeeding in malnourished frail older patients (OREF)

Optimizing refeeding in malnourished frail older patients (OREF) - Optimized refeeding (OREF)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00017324

Enrollment

300

Registered

2019-06-05

Start date

2019-05-29

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E00-E90

Interventions

Group 1: Intervention Group: The following interventions (optimized protocol) will be performed on 150 prospective patients in intervention group: - Screening for micronutrient deficiencies, including

Eligibility

Sex/Gender

All

Age

70 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age >70 years - Malnutrition defined as Mini Nutritional Assessment Short Form (MNA-SF) 10% of initial body weight in 6 months or shorter - Indication for nutritional support - The patient is expected to be hospitalized for at least 14 days in the geriatric department - Ability to participate in the study - Written consent of the patient

Exclusion criteria

Exclusion criteria: - Severe dementia - Severe depression - Severe dysphagia - Tube feeding, expected for more than 2 weeks - Palliative situation (mortality within the next 3 months is very likely) - Significantly reduced cognitive abilities (Mini–Mental State Examination (MMSE) <20 or Montreal Cognitive Assessment (MoCA)

Design outcomes

Primary

Measure	Time frame
Complications (combined endpoint of infections, falls, unplanned hospital readmission, mortality) in hospital and after three and six months	—

Secondary

Measure	Time frame
Secondary endpoint - treatment and rehabilitation success (comparison of functional status at admission and at discharge) and - sustained treatment and rehabilitation success (comparison of mobility at time of hospital admission, discharge, at 3 and 6 months) Tertiary outcome (only in intervention group) - determining nutritional status, including macro- and micronutrient status, - establishing and evaluating of REE and TEE in frail older patients, - establishing determinants of variation of REE, - determining incidence of RFS (incident and full-blown) and - evaluation of the effectiveness of management of Refeeding Syndrome.	—

Measure

Time frame

Secondary endpoint - treatment and rehabilitation success (comparison of functional status at admission and at discharge) and - sustained treatment and rehabilitation success (comparison of mobility at time of hospital admission, discharge, at 3 and 6 months) Tertiary outcome (only in intervention group) - determining nutritional status, including macro- and micronutrient status, - establishing and evaluating of REE and TEE in frail older patients, - establishing determinants of variation of REE, - determining incidence of RFS (incident and full-blown) and - evaluation of the effectiveness of management of Refeeding Syndrome.

—

Countries

Germany

Contacts

Public ContactMaryam Pourhassan

Department for Geriatric Medicine, Marien Hospital Herne – University Hospital, Ruhr-Universität Bochum, Herne

maryam.pourhassan@ruhr-uni-bochum.de+4923234995937

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026