The effects of two vasopressors (phenylephrine and norepinephrine) on oxidative stress level during elective cesarean section performed in spinal anesthesia. O82
Conditions
Interventions
Group 1: 20 parturients who will receive phenylephrine infusion, titrated to keep parturients blood pressure within ±5% of basal values
Group 2: 20 parturients who will receive norepynephrine infusion
Sponsors
Clinic of Gynaecology and Obstetrics University Clinical centre Nis
Eligibility
Sex/Gender
Female
Age
19 Years to 35 Years
Inclusion criteria
Inclusion criteria: Patients ASA I and II status, scheduled for elective caesarean section in spinal anesthesia who have given written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria include contraindications and patients’ refusal of spinal anesthesia, known cardiac, respiratory, neurologic, renal, endocrine, psychiatric disorders, history of drug or alcohol abuse, morbid obesity, preeclampsia, active labor, known fetal congenital abnormalities or signs of fetal compromise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary goal is to compare the effects of phenylephrine and norepinephrine on maternal and umbilical oxidative stress and therefore conclude which of the used drugs has a better effect. | — |
Secondary
| Measure | Time frame |
|---|---|
| Our secondary goal is to compare the effects of phenylephrine and norepinephrine on maternal hemodynamics, on the occurrence of nausea and vomiting, on neonatal Apgar score and umbilical gas analysis. | — |
Countries
Serbia
Contacts
Public ContactMarija Kutlesic
Clinic of Gynaecology and Obstetrics University Clinical Centre Nis
Outcome results
None listed