C71
Conditions
Interventions
Group 1: twice-daily rnTMS (1 Hz, 30 minutes, 1800 pulses/ session), duration of rnTMS depends on the individually available time until surgical resection (minimum 5 days, maximum 28 days)
Group 2: tw
Sponsors
Klinik für Neurochirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Supratentorial glioma grade II – IV in a motor relevant area, (2) Infiltration of primary motor cortex or distance between tumor and corticospinal tract below 8mm (Rosenstock et al., 2017), (3) Study participation does not delay surgery, (4) Age > 18 years, (5) Able to give written informed consent
Exclusion criteria
Exclusion criteria: (1) Contraindications for receiving an MRI scan, (2) Contraindications for undergoing a TMS examination, (3) more than one seizure per week, (4) Surgery scheduled <5 days after potential inclusion, (5) Pregnancy, (6) Missing informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Motor status measured with the BMRC for upper extremities 3 months postoperatively - Gross total resection rate | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Motor status as measured by the BMRC (British Medical Research Council) score for upper extremities 7 days postoperatively, (2) Functional connectivity of the motor system in the resting-state fMRI after the rnTMS intervention, (3) Health-related quality of life (EORTC BN-20) 7 days and 3 months postoperatively, (4) Action Research Arm Test (ARAT) 7 days and 3 months postoperatively | — |
Countries
Germany
Contacts
Public ContactMelina Engelhardt
Klinik für Neurochirurgie, Charité Universitätsmedizin Berlin
Outcome results
None listed