S28 T89 T81 T88 T79 T93 T94 T90 I97 R57 I50 D65 V99
Conditions
Interventions
Group 1: Group 1: healthy volunteers
non-interventional other study
monocenter study
In both groups blood sampling will be performed. There are no planned special other interventions.
For group 1, w
Sponsors
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Frankfurt, Goethe Universität
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age > 18 years - Polytrauma with an ISS = 16 - regular termination of the "shock room" phase - signed informed consent
Exclusion criteria
Exclusion criteria: - patients younger then 18 - burn injury - death within 24 hours post trauma - ISS < 16
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - cytokine-/chemokine profiles - coagulation factors - miRNA - cell damage and function marker - cells - organ functions - diagnoses - duration of the stay at the intensive care unit and hospital - organ failure, mortality Time points for sampling: - upon admission - day 1 - day 2 - day 3 - day 5 - day 7 - day 10 | — |
Secondary
| Measure | Time frame |
|---|---|
| - differential blood analysis (clinical routine) - infections (pneumonia, wound infections, etc.) (clinical routine) - SIRS, severe SIRS (clinical routine) - sepsis, severe sepsis, septic shock - shock severity (katecholamin concentration) - organ dysfunctions (SOFA score) - injury severity (ISS) - disease severity (APACHE II, SAPS II, SAPS 3) - regenerative disturbances (clinical routine) - complications (clinical routine) - mortality - clinical data from the German Trauma Registry - transfusion (clinical routine, BGAs) - perioperative complications e.g. lung embolism, myocardial infarction | — |
Countries
Germany
Contacts
Public ContactIngo Marzi
Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Frankfurt, Goethe Universität
Outcome results
None listed