Healthy volunteers G90
Conditions
Interventions
Group 1: 6 weeks of therapeutic GMI-training, 6 weeks with proceeding standard home-therapy. Study is designed din a cross-sectional design
Group 2: Healthy controls
Sponsors
Dr. med. Sebastian Strauß, Klinik u. Poliklinik für Neurologie u. Institut für DiagnostischeRadiologie der Universität Greifswald
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of CRPS (Budapest criteria) in chrionic stadium (>6months) in an upper limb
Exclusion criteria
Exclusion criteria: severe mental disorder abuse of drugs severe paresis of the affected Hand nerve damage at affected hand contraindications for TMS and fMRI: -Epilepsia, metallic implants, pacemaker,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity (visual analogue scale, after the 6 weeks training period) | — |
Secondary
| Measure | Time frame |
|---|---|
| Activation in areas processing discriminatory aspects of pain -fMRI Activity in the right intraparieltal sulcus (ISP), primary sensorimotor cortex contralateral to the affected hand, subcortical structures (putamen, ncl subthalamicus, ncl accumbens, thalamus), left lateral orbitofrontal sulcus during a mental rotation fMRI-task Association between finger-representation (fmRI) and sensory-motor function at affected side Intracortical inhibition at affected Hemisphere (TMS) sensory threshold (Freyhair-filamente), spatial tactil resolution (Domes), two-point discrimination threshold (wheel-discriminator) at fingertips of both hands Daily-use of the affected Hand (Accelerometer) self-reported usage of the hand (Dash-questionaire) | — |
Countries
Germany
Contacts
Public ContactSebastian Strauss
Dr. med. Sebastian Strauß, Klinik u. Poliklinik für Neurologie u. Institut für DiagnostischeRadiologie der Universität Greifswald
Outcome results
None listed