V99 S00 S06 S01 S02 S03 S07 S09 R04 R02 J96 R09 D65 I26 S26 I50 I60 I61 R57 I97 A41 J80 N17 K72 S20 S30 S40 S50 T20 T90 T91 T92 T93 T94 T95 T98 T68 T79 T80 T88 T81 T82 T83 T84 T85 T89 S23 S24 S25 S26 S27 S28 S29
Conditions
Interventions
Group 1: Group 1: Healthy volunteers
In both groups blood sampling will be performed. There are no planned special other interventions.
Group 1 is the reference group, and blood will be taken only
Sponsors
Klinik für Unfall-, Hand- und WiederherstellungschirurgieUniversitätsklinikum Frankfurt der Goethe Universität
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - (Poly)trauma with an ISS = 16 - preclinical time < 120 min - regular termination of the "shock room" phase - informed consent
Exclusion criteria
Exclusion criteria: - patients younger then 18 - death within 24 hours post trauma - ISS < 16 - kardiopulmonal reanimation - gravidity - patients who underwent immunosuppressive or chemotherapy within the last three months - Immune suppressive therapy - HIV, hepatitis A, B, C, HCV, CMV - kidney dialysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - cytokie-/chemokine profiles - coagulation factors - complement factors - cell damage and function marker - DAMPs and PAMPs - cell s - organ functions - diagnoses - duration of the stay at the intensive care unit and hospital - organ failure, mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| - mediators - stem cells - cell marker - protein/gene expressions - differential blood analysis - infections - SIRS - sepsis - shock - organ dysfunctions - injury - regenerative disturbances - complications - mortality - transfusion - perioperative complications | — |
Countries
Germany, Switzerland
Contacts
Public ContactMarlene Bellen
Klinik für Unfall-, Hand- undWiederherstellungschirurgieKlinik der Goethe-Universität
Outcome results
None listed