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Influence of an inhalative vs. intravenous sedation regimen on the spatial distributions of regional ventilation and transpulmonary pressures in mechanically ventilated patients

Influence of an inhalative vs. intravenous sedation regimen on the spatial distributions of regional ventilation and transpulmonary pressures in mechanically ventilated patients - Lung function IsoPro

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00017198
Enrollment
10
Registered
2019-07-23
Start date
2023-06-09
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J96.0

Interventions

Group 1: Lung function of 10 intensive care patients with artificial respiration will be measured continuously while changing the sedation schema from intravenous to inhalativ.

Sponsors

Universitätsklinik für Anästhesiologie, operative Intensivmedizin, Rettungsmedizin, Schmerztherapie, Campus OWL, Klinikum Herford AöR
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Patients who have received intravenous sedation with propofol for at least 24 hours and 2) who require a change of sedation regime for clinical reasons.

Exclusion criteria

Exclusion criteria: 1) pregnancy 2) minors < 18 years old 3) allegies to propofol and/or isoflurane 4) susceptibility to malignant hyperthermia 5) application of tidal volumes <200 ml 6) risk of increased intracranial pressure and no possibility of continuous ICP/CPP monitoring

Design outcomes

Primary

MeasureTime frame
The change of distribution of ventilation in mechanically ventilated intensive care patients within 24 hours after conversion of sedation from propofol to isoflurane.—

Countries

Germany

Contacts

Public ContactDietrich Henzler

Universitätsklinik für Anästhesiologie, operative Intensivmedizin, Rettungsmedizin, Schmerztherapie, Campus OWL, Klinikum Herford AöR

dietrich.henzler@klinikum-herford.de+49 (0)5221 94 2481

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026