J80
Conditions
Interventions
Group 1: Observational study. Data on ventilation distribution, transpulmonary pressure, ventilator pressures and regional diaphragmatic excursion will be collected during routine clinical procedures.
Sponsors
Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Acute respiratory distress Syndrome (ARDS) according to the Berlin Definition Computed tomography images of chest present and not older than 24 hours
Exclusion criteria
Exclusion criteria: Age < 18 years, pregnancy, cardiac pacemaker or other active implants, burns or thoracic skin lesions, high-grade chronic obstructive pulmonary disease, hemodynamic instability despite adequate fluid resuiscitation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of model-predicted tidal volume and driving pressure (airway plateau pressure - positive end-expiratory airway pressure) after a decremental positive end-expiratory pressure trial | — |
Secondary
| Measure | Time frame |
|---|---|
| Transpulmonary pressure (actual vs. model-predicted) end-expiratory lung volume (actual vs. model-predicted) regional ventilation distribution as assessed by EIT (%ventral, %dorsal, %right, %left; actual vs. model-predicted) regional diaphragmatic excursion, as assessed by ultrasound (actual versus model-predicted) Ratio of arterial partial pressure of oxygen to inspired fraction of oxygen after PEEP-Trial (actual vs. model predicted) arterial partial pressure of carbon dioxide (actual versus model predicted) | — |
Countries
Germany
Contacts
Public ContactTobias Becher
Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel
Outcome results
None listed