Butyrylcholinesterase activity as a risk factor of postoperative delirium in cardiosurgical patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00017144

Enrollment

Registered

2019-05-15

Start date

2019-02-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F05.8

Interventions

Group 1: Patients scheduled for cardiac surgery, at age > 60 years, will pre-operatively examined the MiniCog-test. Activity of plasma butryrylcholinesterase will be determined preoperatively and 1 da

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: Cardiac surgery under general anaesthesia, informed consent, ability to perform brief cognitive test

Exclusion criteria

Exclusion criteria: Emergency patients, not being able to perform cognitive test, age < 60 yrs

Design outcomes

Primary

Measure	Time frame
Is there a difference between pre- and postoperative activity of the plasma butyrylcholinesterase in cardio surgical patients?	—

Secondary

Measure	Time frame
1. Is the activity of butyrylcholinesterase in the group of patients, who later develop delirium, already reduced pre-operatively, compared to those who do not? 2. Is delirium more frequent in patients, whose butyrylcholinesterase-activity decreases after surgery? 3. Can the pre- or postoperative activity of butyrylcholinesterase serve as a risk factor of delirium? 4. Are differences between patients being operated on with or without cardiopulmonary bypass?	—

Measure

Time frame

1. Is the activity of butyrylcholinesterase in the group of patients, who later develop delirium, already reduced pre-operatively, compared to those who do not? 2. Is delirium more frequent in patients, whose butyrylcholinesterase-activity decreases after surgery? 3. Can the pre- or postoperative activity of butyrylcholinesterase serve as a risk factor of delirium? 4. Are differences between patients being operated on with or without cardiopulmonary bypass?

—

Countries

Germany

Contacts

Public ContactUlf Günther

Klinikum Oldenburg AöR Universitätsklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie

Guenther.Ulf@klinikum-oldenburg.de04414032571

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026