J80
Conditions
Interventions
Group 1: Mechanically ventilated patient with ARDS by Berlin Definition.
Pressure-, flow- and surface EMG data is gathered during the course of ARDS treatment. Additionally, an ultrasound of the diaph
Sponsors
Charité Campus Virchow-Klinikum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • ARDS due to pneumonia defined by Berlin Definition • Age = 18 Years • Admitted to a participating ICU at Charité Universitätsmedizin Berlin - Campus Virchow
Exclusion criteria
Exclusion criteria: • preexisting severe lung disease such aswie z.B. o COPD (GOLD 3-4) o pulmonary fibrosis o cystic fibrosis • unfavorable prognosis (death is expected within hours, in spite of maximal therapy) • pregnant or breastfeeding patients • patient is placed in a penal institution • consent cannot be obtained by legal proxy • patients advance directives exclude or argue against participation in a trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ration of electrical (EMG) and mechanical (pressure/flow) signal of the respiratory muscles at the three following times of measurement: • acute phase (within the first 48h after admission to a study-ICU) • at the first reduction of sedation (Goal-RASS =-2) • at the beginning of discontinuous Weaning (CPAP) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Ratio of sEMG of the diaphragm and other respiratory muscles • maximal inspiratory and exspiratory flow • transpulmonary pressure • airway occlusion pressure • respiratory fatigue during assisted ventilation • diaphragmatic thickness (ultrasound) | — |
Countries
Germany
Contacts
Public ContactSteffen Weber-Carstens
Charité - Universitätsmedizin BerlinCampus Virchow-KlinikumKlinik für Anästhesiologie m.S. operative Intensivmedizin
Outcome results
None listed