F50.0
Conditions
Interventions
Group 1: freely available vegan PUFA (Docosahexaensäure (DHA) 1500mg/Eicosapentaensäure (EPA) 900mg) incl. 15mcg Vit. D3 („Opti3 Omega3 EPA&DHA),
two times a day
Group 2: Placebo
Sponsors
Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
Eligibility
Sex/Gender
All
Age
13 Years to 20 Years
Inclusion criteria
Inclusion criteria: 1. Female and male patients >=13 and <20 2. Written Informed consent. 3. Patient with typical and atypical anorexia nervosa according to DSM-5 4. Healthy control subjects without current psychiatric disorder according to ICD-10 and without eating disorders in the past.
Exclusion criteria
Exclusion criteria: 1. Organic brain disease 2. psychotic disorder 3. bipolar disorder 4. substance use disorder 5. IQ < 80 6. insufficient knowledge of German language 7. Organic disorder with influence on gastrointestinal tract for example diabetes or inflammtory bowel diseases 8. antibiotic use during the previous 6 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Approximation of microbiome (MI) composition after PUFA (poly-unsaturated fatty acids) administration to that of heathly normal-weight age-matched controls which in consequence leads an increase in body weight as measured in body mass index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondarily, an improvement in gastrointestinal discomfort, a reduction in depressive symptoms and a reduction in inflammatory processes and intestinal permeability may be associated with these MI changes. | — |
Countries
Germany
Contacts
Public ContactJochen Seitz
Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen
Outcome results
None listed