Oral Health of Centenarians Part A: clinical and sociological cross-sectional examination of oral health, oral health-related quality of life, masticatory function and nutrition Part B:Oral metagenome, proteome and immunological status of centenarians, centenarian offspring and an offspring birth cohort

Oral Health of Centenarians Part A: clinical and sociological cross-sectional examination of oral health, oral health-related quality of life, masticatory function and nutrition Part B:Oral metagenome, proteome and immunological status of centenarians, centenarian offspring and an offspring birth cohort - HD100Z

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00017128

Enrollment

200

Registered

2019-05-20

Start date

2019-05-04

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K02 K05 K13

Interventions

Group 1: Patients aged 100 years and older (interview, dental examination, plaque and salivary samples) Group 2: centenarian offspring (interview, dental examination, plaque and salivary samples) Grou

Eligibility

Sex/Gender

All

Age

100 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria for centenarians: - the study participant is age 100 years or older - the study participant is able to give consent Additionally in the second recruiting round (starting 2022): For the descendants of the centenarians: - The study participant is a direct descendant of the centenarians Study participants (son / daughter or grandchild) - The study participant is able to give consent - The study participant is 18 years or older For the control group of centenarians' offspring: - The study participant must match a recruited offspring within the framework of an adapted control group according to their age and gender. - The study participant is not a direct descendant (son, daughter, grandchild) of a person aged 100+. - The study participant is able to give consent - The study participant is 18 years or older

Exclusion criteria

Exclusion criteria: - Patients missing one or more requirements in the inclusion criteria - Patients with incomplete consent form

Design outcomes

Primary

Measure	Time frame
Part A: clinical and sociological cross-sectional examination of oral health, oral health-related quality of life, masticatory function and nutrition Oral health indices • DMFT / DMFS index: 1. Number of teeth or tooth surfaces destroyed by caries "D" (Decayed) 2. Number of missing teeth "M" (Missing) 3. Number of filled teeth or tooth surfaces "F" (Filled). When assessing the tooth surface level, the DMFS value ("S" = surfaces) is calculated from the addition of the affected tooth surfaces. • Erosion: index value according to the Basic Erosive Wear Examination (BEWE) • Root caries: Root Caries Index (RCI) • Periodontal parameters: Bleeding on Probing (BOP), CDC / AAP case classification, Community Periodontal Index (CPI, without Treatment Needs [TN]) • Type of prosthetic restoration (according to Kerschbaum) • Dental functional capacity: Resilience levels according to Nitschke • Salivatory flow rate • Chewing efficiency according to Schimmel et al. • Oral health-related quality of life: Geriatric Oral Health Assessment Index (GOHAI) in the German version • Malnutrition risk factor: Mini Nutritional Assessment - Short Form (MNA®-SF) Screening Score Part B:Oral metagenome, proteome and immunological status of centenarians, centenarian offspring and an offspring birth cohort • Microbiome determination, (16S rRNA amplicon sequencing and metagenomic sequencing) • Immunological factors: • protein activity: lysozyme; Immunoglobulins (IgA, IgM, IgG) • Quantitative mass spectrometry-based proteomics • Cellular immune response: CD4 / CD8 ratio	—

Measure

Time frame

Part A: clinical and sociological cross-sectional examination of oral health, oral health-related quality of life, masticatory function and nutrition Oral health indices • DMFT / DMFS index: 1. Number of teeth or tooth surfaces destroyed by caries "D" (Decayed) 2. Number of missing teeth "M" (Missing) 3. Number of filled teeth or tooth surfaces "F" (Filled). When assessing the tooth surface level, the DMFS value ("S" = surfaces) is calculated from the addition of the affected tooth surfaces. • Erosion: index value according to the Basic Erosive Wear Examination (BEWE) • Root caries: Root Caries Index (RCI) • Periodontal parameters: Bleeding on Probing (BOP), CDC / AAP case classification, Community Periodontal Index (CPI, without Treatment Needs [TN]) • Type of prosthetic restoration (according to Kerschbaum) • Dental functional capacity: Resilience levels according to Nitschke • Salivatory flow rate • Chewing efficiency according to Schimmel et al. • Oral health-related quality of life: Geriatric Oral Health Assessment Index (GOHAI) in the German version • Malnutrition risk factor: Mini Nutritional Assessment - Short Form (MNA®-SF) Screening Score Part B:Oral metagenome, proteome and immunological status of centenarians, centenarian offspring and an offspring birth cohort • Microbiome determination, (16S rRNA amplicon sequencing and metagenomic sequencing) • Immunological factors: • protein activity: lysozyme; Immunoglobulins (IgA, IgM, IgG) • Quantitative mass spectrometry-based proteomics • Cellular immune response: CD4 / CD8 ratio

—

Secondary

Measure	Time frame
explorative study, see primary outcome criteria	—

Countries

Germany

Contacts

Public ContactCaroline Sekundo

Poliklinik für Zahnerhaltungskunde der Klinik für Mund-, Zahn- und Kieferkrankheiten des Universitätsklinikums Heidelberg

caroline.sekundo@med.uni-heidelberg.de+496221/5639886

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026