Functional training for persons with multiple sclerosis

Conditions

G35

Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger et al. (18 authors)

Acta Physiologica2026-01-28

10.1111/apha.70166

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns

Marie Kupjetz, Martin Langeskov‐Christensen, Morten Riemenschneider, Stefan Inerle, Uwe Ligges et al. (20 authors)

Neurology Neuroimmunology & Neuroinflammation2025-09-18

10.1212/nxi.0000000000200461

Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis - a community-based randomized controlled trial.

Proschinger S, Joisten N, Rademacher A, Schlagheck ML, Walzik D, Metcalfe AJ, Oberste M, Warnke C, Bloch W, Schenk A, Bansi J, Zimmer P.

2019-12-0612 citations

10.1186/s12883-019-1544-7

Interventions

Group 1: Intervention group: The participants will conduct three times a week over 10 weeks in a non-stationary and community-based setting with regular combined functional endurance and resistance tr

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Relapsing remitting multiple sclerosis; EDSS-Scale (Expanded Disability Status Scale): 0-4

Exclusion criteria

Exclusion criteria: Acute episode or exacerbation of multiple sclerosis symptoms during intervention, cardiac preload, concomitant disease state (internistic or neurological) affecting study end points (e.g. tumor diseases), orthopaedic diseases excluding from the exercise program, pregnancy or breast feeding

Design outcomes

Primary

Measure	Time frame
matrix-metalloproteinases in the Serum (t0, t1, t2)	—

Secondary

Measure	Time frame
Number and proportions of further circulating immune markers associated with MS and exercise (t0, t1, t2): metabolites of the Tryptophan-Kynurenine pathway and enzymes, cytokines, lipid markers and T-cells Strength (t0, t2): Hypothetical One Repetition Maximum strength in relevant muscle groups Endurance capacity (t0, t2): Peak oxygen uptake (VO2peak) reflecting their cardiorespiratory fitness measured during a maximal incremental exercise test on a cycle ergometer. Further secondary outcomes: actigraphic data (t0, t1, t2); body composition (BIA) (t0, t2) cognitive Performance (t0, t2), i.e. information processing speed, verbal memory and visual memory; questionnaires to measure fatigue (t0, t2), depression (t0, t2), sleeping quality (t0, t2) and quality of life (t0, t2)	—

Measure

Time frame

Number and proportions of further circulating immune markers associated with MS and exercise (t0, t1, t2): metabolites of the Tryptophan-Kynurenine pathway and enzymes, cytokines, lipid markers and T-cells Strength (t0, t2): Hypothetical One Repetition Maximum strength in relevant muscle groups Endurance capacity (t0, t2): Peak oxygen uptake (VO2peak) reflecting their cardiorespiratory fitness measured during a maximal incremental exercise test on a cycle ergometer. Further secondary outcomes: actigraphic data (t0, t1, t2); body composition (BIA) (t0, t2) cognitive Performance (t0, t2), i.e. information processing speed, verbal memory and visual memory; questionnaires to measure fatigue (t0, t2), depression (t0, t2), sleeping quality (t0, t2) and quality of life (t0, t2)

—

Countries

Germany

Contacts

Public ContactPhilipp Zimmer

Deutsche Sporthochschule Köln, Institut für Kreislaufforschung und SportmedizinAbteilung molekulare und zelluläre Sportmedizin

p.zimmer@dshs-koeln.de004922149825440

Outcome results

None listed