obesity
Conditions
Interventions
Group 1: Biopsy of the liver, visceral and subcutaneous fat, blood sample, stool sample, ultrasound (ARFI, FirboScan), oGTT, questionaire
Sponsors
Klinikum Nordstadt, Klinikum Region Hannover GmbHKlinik f. Allgemein-, Viszeral- und Gefäß- und Adipositas(AVGA)chirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Primary elective bariatric operation - Obesity with a BMI >35kg/m2 (obesity >II) - Patient volunteers >=18 years of age and consentable
Exclusion criteria
Exclusion criteria: - Involvement in another study investigating NASH - Alcohol abuse (> 20g/d for women, 40 g/d for men) - Redo-operations - Diabetes mellitus Typ 1 - Not willing to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is defined as the improvement of fibrosis (>1 degree of fibrosis) 1 and 3 years after bariatric surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome is the histologic improvement of NASH (reduction of NAS>1), cardiovascular risk profile reduction, including blood pressure setting, anti-hypertensive and anti-diabetic co- medication, and the degree of obesity 1 and 3 years after bariatric surgery. Additionally, histologic measures are correlated with sonographic measures. | — |
Countries
Germany
Contacts
Public ContactClara Böker
Klinikum Nordstadt, Klinikum Region Hannover GmbHKlinik f. Allgemein-, Viszeral- und Gefäß- und Adipositas(AVGA)chirurgie
Outcome results
None listed