prenatal und postnatal maternal mental and physical health prenatal und postnatal mental and physical health of the offspring
Conditions
Interventions
Group 1: 1. control group: mentally stable women
Group 2: 2. control group: mentally stressed women without intervention
Group 3: Mentally stressed women with psychotherapeutic intervention and follow
telemedical intervention from week 26 postpartal until 52 weeks postpartal)
Sponsors
Universitätsmedizin Greifswald, Klinik und Poliklinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
Female
Age
17 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant women are included if they are between 18 and 45 years of age and at the end of the second pregnancy trimester (25th to 29th week of pregnancy).
Exclusion criteria
Exclusion criteria: Women with multiple pregnancies or foreseeable developmental disabilities of the fetus, as well as women requiring withdrawal, exhibiting low motivation for therapy, suffering alcohol or drug addiction (DIPS), having severe psychosis or reporting suicidality (DIPS) need to be excluded. In addition, women being submitted to a recent psychiatric or psychotherapeutic treatment (or another study including such treatments) have to be excluded in order to impede confounding of therapeutic effects. Women who are 17 years old at the screenings, can be included, but will be excluded if they won't reach the age of 18 at delivery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concerning the women, interventions are expected to reduce mental stress (assessed by the BSI-18 to screening, baseline and 8-week, 26-week and 52-week follow-ups) | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) concerning the women i. to improve quality of life ii. to enhance resilience iii. to increase rates of breastfeeding mothers (2) Concerning the children, interventions are expected i. to reduce rates of preterm birth as well as complications during childbirth ii. to reduce regulation disorders iii. to reduce developmental retardations iv. to strengthen physical health (3) Concerning women and children, interventions are expected i. to improve mother-child-interaction and to strengthen bonding (MAAS, PBQ, CARE Index) ii. to lower cortisol levels and to increase oxytocin levels in both mother and child The outcomes (1) to (3) are expected to converge to those of healthy mothers and children in the control group. In contrast, it is assumed that these outcomes depart in the group of stressed women without intervention from those of the intervention group. (4) In addition, the results of the study will lead to the development of a qualification measure for health professionals who will be trained to detect mental stress, and in turn to refer those women to professional institutions. The study aims to examine by explorative analysis hormonal transmissions between mother and child. Therefore, a biobank will be built up to analyse DNS-sequences, RNA-expression, miRNA as well as DNA methylation and other metabolomics. In particular, the study scrutinizes how the development of the HPA-axis in infants is shaped by depressive symptoms of the mother and how the HPA-axis in mother and infants is influenced by the different interventions of the study. Moreover, the constituents of breast milk will be analyzed, as well as hormonal responses of mother and child to stress. Quantitative and qualitative analysis of the subjective satisfaction of the woman as well as of the efficacy and feasability of the intervention study. | — |
Countries
Germany
Contacts
Public ContactJuliane Corleis
Universitätsmedizin Greifswald, Klinik und Poliklinik für Psychiatrie und Psychotherapie
Outcome results
None listed