healthy subjects
Conditions
Interventions
Group 1: Vibramycin® Tabs (Doxycyline), 200mg capsule, oral administration, single-dose.
6 experiments will examine whether aversive memories of healthy participants can be influenced by the antibiot
Sponsors
Department of Psychiatry, Psychotherapy, Psychosomatics, University of Zurich
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - Informed Consent as documented by signature - Age 18 – 40 years
Exclusion criteria
Exclusion criteria: • Allergy to doxycycline or to any other ingredient in the named drugs • Use of any drugs in the 2 weeks prior to the study with the exception of contraceptive drugs and incidental use of NSARs or paracetamol • Women who are pregnant or breast feeding, • Intention to become pregnant during the course of the study, • Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration • Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.) • Any history of psychiatric, neurological, addiction, or systemic/rheumatic disease • Known or suspected non-compliance, drug or alcohol abuse • Inability to follow the procedures of the study, e.g. due to language problems • Participation in another study with investigational drug within 30 days preceding and during the present study, • Previous enrolment into the current study, • Members of the study team and their family members and dependants • Regular work in a medical profession • Life time history of being a victim of interpersonal violence or other potentially traumatic experience, or close relative of a person with such history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints are updated prompt to the start of a new experiment. Experiment 1 and 2: Fear-potentiated startle, measured via eyeblink EMG of the M. orbicularis oculi and quantified according to Khemka et al. (2017) Detailed analysis plan: https://osf.io/6kj5u/. Experiment 5: Quantity and distress of intrusion in an intrusion diary during one week following the trauma film | — |
Secondary
| Measure | Time frame |
|---|---|
| Experiment 1 und 2: SCR (skin conductance response), respiration amplitude, heart period measured with ECG (Electrocardiogram), pupil reaction, neuropsychological tests (e.g. VLM-T), questionnaires (STAI). Experiment 5: Questionnaires (e.g. STAI, BIS-BAS), SCR (skin conductance response), respiration amplitude, heart period measured with ECG (Electrocardiogram), neuropsychological tests (e.g. VLM-T). | — |
Countries
Switzerland
Contacts
Public ContactJelena Wehrli
Department of Psychiatry, Psychotherapy, Psychosomatics, University of Zurich
Outcome results
None listed