Patients undergoing elective surgery who have an indication to use arterial blood pressure monitoring.
Conditions
Interventions
Group 1: Patients undergoing general anesthesia with Propfol, Sufentanil and Atracurium will receive blood samples at defined times and plasma concentrations of each drug will be measured.
Sponsors
Universitätsklinikum des Saarlandes
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Written consent of the patient; Electively operated patients under general anesthesia; The indication due to surgery and / or anesthesia to establish arterial blood pressure monitoring
Exclusion criteria
Exclusion criteria: Intolerance to propofol, sufentanil or atracurium; Children and adolescents (<18 years of age); Patients undergoing emergency surgery; Drug abuse; Positive HIV test; Positive hepatitis test; Pregnancy; Patients in whom the indication for anesthesia with volatile anesthetics is made; Patients who are not indicated to use arterial blood pressure monitoring; Rejection by the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Model parameters with inter- and intraindividual variability (variance) for compartment volumes, clearances and transfer constants of a population-pharmacokinetic-pharmacodynamic model of general anesthesia for propofol, sufentanil and atracurium taking into account the EEG (bispectral index) | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigation of the influence of co-variables on parameters within the pharmacokinetic model. | — |
Countries
Germany
Contacts
Public ContactTobias Hüppe
Center of Breath Research Universitätsklinikum des Saarlandes Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Outcome results
None listed