Comparing examination of the effect of transcranial direct current stimulation (tDCS) of genetically defined ataxias and in a mouse model.

Comparing examination of the effect of transcranial direct current stimulation (tDCS) of genetically defined ataxias and in a mouse model. - CBI-SCA6

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00017021

Enrollment

Registered

2019-06-12

Start date

2019-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SCA6 G11.2

Interventions

Group 1: I. CBI Subjects: 15 patients with genetically proven spinocerebellar ataxia type 6 (SCA6). Baseline measures: General medical and neurologic examination to exclude disorders other than

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Written informed consent of the patient/paticipant 2. Minimum age: 18 years 3. Patients: Existence of a genetically secured SCA6 4. Sufficient knowledge of the German language to understand the written consent and the experimental instructions

Exclusion criteria

Exclusion criteria: 1. Healthy controls: Existence of a neurological (incl. epileptic seizures), psychiatric or severe orthopaedic disorders 2. SCA6 patients: Existence of neurological disorders other than SCA6 (incl. epileptic seizures), psychiatric or severe orthopaedic disorders 3. Drug oder alcohol abuse 4. Intake of centrally-acting drugs 5. Persons with consuming diseases or in bad general health condition 6. (Adult) persons that are not contractually capable and persons in regulatory or judical custody

Design outcomes

Primary

Measure	Time frame
Change of Cerebellar Brain Inhibition by application of cerebellar transcranial Direct Current Stimulation	—

Secondary

Measure	Time frame
1. Change of eyeblink conditioning by application of cerebellar tDCS 2. Correlation between disease duration and change of CBI 3. Correlation between ataxia severity (using ataxia-scores; SARA, ICARS, SCAFI) and change in CBI 4. Comparison with the mouse model of SCA6	—

Countries

Germany

Contacts

Public ContactAndreas Gustafsson Thieme

Klinik für Neurologie, Universitätsklinikum Essen

andreas.thieme@uk-essen.de0201-723-83221

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026