Quantification of recruitable alveolar collapse and overdistension during laparoscopic GYNEcological surgery and mechanical VENTilation

Quantification of recruitable alveolar collapse and overdistension during laparoscopic GYNEcological surgery and mechanical VENTilation - GYNEVENT-Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00016974

Enrollment

Registered

2019-03-14

Start date

2019-03-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical ventilation during laparoscopic surgery

Interventions

Group 1: Decremental PEEP-trial in steps of 2 mbar, starting with 20 mbar, down to 4 mbar

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients (m/f/d) with planned laparoscopic surgery in Trendelenburg position, written informed consent.

Exclusion criteria

Exclusion criteria: Body mass index > 35 kg/m2; metal chest implants, open thoracic lesions, pregnancy, participation in other interventional studies, chronic lung diseases

Design outcomes

Primary

Measure	Time frame
Lowest PEEP level with no relevant alveolar collapse in 30° Trendelenburg position with capnoperitoneum. "Relevant" defined as more than 3% of relative collapse when analyzing the whole PEEP trial.	—

Secondary

Measure	Time frame
1. Percentage of relative lung overdistension during mechanical ventilation at the PEEP level corresponding to the primary end point 2. PEEP level with same percentage of relative overdistension and relative collapse 3. Lowest PEEP level with no relevant alveolar collapse after induction of anesthesia in horizontal position without capnoperitoneum (for definition of "relevant" see primary outcome) 4. PEEP level with highest global respiratory system compliance 5. Correlation between intraabdominal pressure and PEEP level necessary for primary end point 6. Blood pressure, heart rate and oxygen saturation at abovementioned PEEP levels in comparison to baseline (baseline = after induction of anesthesia, PEEP 5 mbar) 7. Influence of duration of capnoperitoneum on ventilation distribution immediately before and after extubation and on oxygen saturation in recovery room (30 minutes after extubation, room air).	—

Measure

Time frame

1. Percentage of relative lung overdistension during mechanical ventilation at the PEEP level corresponding to the primary end point 2. PEEP level with same percentage of relative overdistension and relative collapse 3. Lowest PEEP level with no relevant alveolar collapse after induction of anesthesia in horizontal position without capnoperitoneum (for definition of "relevant" see primary outcome) 4. PEEP level with highest global respiratory system compliance 5. Correlation between intraabdominal pressure and PEEP level necessary for primary end point 6. Blood pressure, heart rate and oxygen saturation at abovementioned PEEP levels in comparison to baseline (baseline = after induction of anesthesia, PEEP 5 mbar) 7. Influence of duration of capnoperitoneum on ventilation distribution immediately before and after extubation and on oxygen saturation in recovery room (30 minutes after extubation, room air).

—

Countries

Germany

Contacts

Public ContactHenning Ohnesorge

Klinik für Anästhesiologie und Operative Intensivmedizin

henning.ohnesorge@uksh.de0431 50020801

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 14, 2026