Contrast-enhanced Ultrasound (CEUS) for determining muscular Perfusion after oral intake of L-Citrulline, L-Arginine, and galloylated epicatechines.

Contrast-enhanced Ultrasound (CEUS) for determining muscular Perfusion after oral intake of L-Citrulline, L-Arginine, and galloylated epicatechines. - CEUS #Bizeps

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00016972

Enrollment

Registered

2019-03-25

Start date

2019-08-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Examination of different sport supplement ingredients for their potency of vasodilation in skeletal muscle.

Interventions

Group 1: Subjects after consumption of 8 grams of L-Citrulline and 3 grams of L-Arginine in 200 milliliters of water Group 2: Subjects after consumption of 300 milligrams of galloylated oligomeres of

Eligibility

Sex/Gender

Male

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Young male subjects who workout in athletic sports regularly (e.g. Fitness/Gym, weightlifting, powerlifting)

Exclusion criteria

Exclusion criteria: • Existing contraindications for contrast agent o Known intolerance for SonoVue® or other ultrasound contrast agents o Cardiac Right-to-left shunt o severe heart failure (NYHA III and IV) o uncontrollable hypertension o severe pulmonary hypertension(>90 mmHg) o acute respiratory distress syndrome o taking Dobutamine while suffering cardiovascular instability o severe pulmonary diseases, in particular severe obstructive pulmonary diseases, ARDS. • Known diseases of the vascular system, liver, kidneys or gastrointestinal tract • smokers • Regular consumption of L-Citrulline, L-Arginin, or Vaso6™ within the last 7 days before CEUS-examination • Consumption of caffeine or nicotine within the last 12 hours before CEUS-examination • physical workout within the last 24 hours before CEUS-examination • adults incapable of consent, missing letter of agreement, or rejection of participation

Design outcomes

Primary

Measure	Time frame
Perfusion of Musculus biceps brachii before and after exercise plus during influence of described Supplement ingredients (see "Arm1-3") Measured by Contrast-enhaced Ultrasound (ECEUS)	—

Secondary

Measure	Time frame
Comparing intensities of cumulative perfusion among each ingredient.	—

Countries

Germany

Contacts

Public ContactChristian Alexander Fischer

Universität Heidelberg, Zentrum für Orthopädie, Unfallchirurgie und Paraplegiologie

christian.fischer@med.uni-heidelberg.de062215635366

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 17, 2026