M81
Conditions
Interventions
Group 1: Patients receiving a dorsal stabilization of the lumbar spine. All patients receive preoperative measdurements of bone quality using TBS, aBMD and BMSi. Additionally, intraoperative vertebral
Sponsors
Charité Campus Charité Mitte
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - patients with degenerative diseases of the spine and the indication for a dorsal stabilization of the lumbar spine using pedicle screws - patients with the indication for osteoporosis diagnostics - consent to participate - capacity for consent
Exclusion criteria
Exclusion criteria: - known tumors - previous surgery including L1-4 - recent or older changes of the vertebrae L1-4 (e.g. fractures) - BMI >35 - Patients with serious damages of the central or peripheral nervous system - Incompliance - alcohol, drug or medicine-dependency - serious psychiatric diseases limiting the understanding of the project plan and the study protocol - pregnant and breast feeding patients - patients not able to give consent for any reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| crosssectional: parameters of bone quality (µCT and histomorphometry of vertebral biopsies as well as in vivo DXA, TBS and BMSi preoperatively) longitudinally: material faillure after 12 and 36 months | — |
Secondary
| Measure | Time frame |
|---|---|
| in vivo measurements of bone quality after 12 and 36 months, laboratory parameters of bone metabolism, clinical parameters like vertebral fractures or standardized scores | — |
Countries
Germany
Contacts
Public ContactYannick Palmowski
Charité Campus Charité Mitte
Outcome results
None listed