Heart rate variability and autonomic physiological functions as a predictor of clinical outcome in neurobiological stimulation therapy, in particular electroconvulsive therapy and vagus nerve stimulation

Heart rate variability and autonomic physiological functions as a predictor of clinical outcome in neurobiological stimulation therapy, in particular electroconvulsive therapy and vagus nerve stimulation - HRV in neurobiological stimulation therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016928

Enrollment

Registered

2019-03-11

Start date

2019-06-18

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32.2 F32.3

Interventions

Group 1: Patients with therapy-resitant depression who receive electroconvulsive therapy or vagus nerve stimulation Group 2: Patients with therapy-resitant depression who do not receive electroconvuls

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Women and men who meet the criteria for therapy-resistant depression and who have been given the indication for electroconvulsive therapy and / or vagus nerve stimulation • Age from 18 • Legally valid consent

Exclusion criteria

Exclusion criteria: Patients who have a contraindication to electroconvulsive therapy or a contraindication to surgery to implant the Nervus Vagus Stimulator

Design outcomes

Primary

Measure	Time frame
There is no endpoint defined. The aim of the study is to investigate whether it is possible to predict the effect of the neurostimulation therapy and the course of the disease by measuring heart rate variability, noninvasive determination of autonomic nervous system parameters and assessing laboratory parameters in the blood.	—

Secondary

Measure	Time frame
There is no secondary outcome defined.	—

Countries

Germany

Contacts

Public ContactSebastian Möller

Klinik für Psychiatrie und PsychotherapieUniversitätsklinikum Bonn

sebastian.moeller@ukbonn.de0228 287-31223

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026