Open wound at the palate
Conditions
Interventions
Group 1: Wound closure with Mucograft Seal (Geistlich Pharma AG, Wolhusen, Switzerland)
Group 2: Wound closure with Mucoderm (Botiss medical AG, Berlin, Germany)
Group 3: Wound closure with Fibrogide
Sponsors
Universität Zürich, Zentrum für Zahnmedizin, Klinik für Rekonstruktive Zahnmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Male and female participants at least 18 of age • Sufficient space between the first molar and the canine for two 6mm biopsies with at least 3mm in between • Systemically healthy • Good oral hygiene (Plaque index <30%) • Absence of periodontal disease (Probing depth exceeding 4mm) • Willingness to wear a splint to cover the palate during the observation period • Sufficiently restored dentition • Informed Consent as documented by signature
Exclusion criteria
Exclusion criteria: • Previous surgeries at the palate • Uncontrolled diabetes • Smoking of more than 15 cigarettes per day • Self-declared pregnancy or breast feeding at the date of inclusion or intending to become pregnant during the course of the study • Allergies against local anaesthetics • Known or suspected non-compliance, drug or alcohol abuse • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant • Participation in another study with investigational drug within the 30 days preceding and during the present study • Previous enrolment into the current study • Enrolment of the investigator, his/her family members, employees and other dependent persons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the progression of wound closure as a percentage of the initial defect at day 7. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes are the defect fill compared to the baseline situation by means of a volumetric analysis, patient reported outcome measures for pain by means of a visual analogue scale and a descriptive histology at 16 and 32 days. | — |
Countries
Switzerland
Contacts
Public ContactStefan P. Bienz
Universität Zürich, Zentrum für Zahnmedizin, Klinik für Rekonstruktive Zahnmedizin
Outcome results
None listed