Perioperative assessment of the remnant liver functional capacity with the 13C methacetin breath test

Perioperative assessment of the remnant liver functional capacity with the 13C methacetin breath test - ReLiF study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00016795

Enrollment

Registered

2019-02-21

Start date

2019-02-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver resection of 3 or more liver segments (according to Couinaud classification) and its effect on liver functional capacity C22 C78.7 C24 D37.6 D13.4

Interventions

Group 1: In this single-centre, prospective study will be enrolled all patients who will undergo a liver resection of three or more liver segments according to Couinaud classification at the Clinic f

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adult patients (> 18 years of age) able to give consent, who will undergo a liver resection of 3 or more liver segments according to Couinaud classification at the Department of General and Visceral Surgery of the Asklepios Klinik Barmbek within one year of the study beginning.

Exclusion criteria

Exclusion criteria: 1. Patients with an allergy to acetaminophen or methacetin. 2. Patients who have received a strong CYP1A2 agonist (e.g., ciprofloxacin, fluvoxamine, enoxacin, verapamil) within the half-life of these substances

Design outcomes

Primary

Measure	Time frame
The LiMAx (maximum liver function capacity) value	—

Secondary

Measure	Time frame
1. The "delta over baseline" (DOB) values at representative times and the DOB curve. 2. Postoperative complications in a 90-day "follow-up" according to the Clavien-Dindo classification and 30- and 90-day mortality correlated with the above-mentioned measurements. 3. The postoperative liver failure (PHLF) as defined by the "50-50 criteria", the "peak bilirubin" value, the International Study Group of Liver Surgery (ISGLS) definition and the "Hyder et al. Risk Score".	—

Measure

Time frame

1. The "delta over baseline" (DOB) values at representative times and the DOB curve. 2. Postoperative complications in a 90-day "follow-up" according to the Clavien-Dindo classification and 30- and 90-day mortality correlated with the above-mentioned measurements. 3. The postoperative liver failure (PHLF) as defined by the "50-50 criteria", the "peak bilirubin" value, the International Study Group of Liver Surgery (ISGLS) definition and the "Hyder et al. Risk Score".

—

Countries

Germany

Contacts

Public ContactGeorgios Makridis

Allgemein- und Viszeralchirurgie Asklepios Klinik Barmbek

gmakridis@joho.de(+4940) 1818822811

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026