General anaesthesia C25
Conditions
Interventions
Group 1: Metabolites (amino acids, carnitines, sugars, phospholipids, sphingolipids, fatty acids, bile acids, zytokines) are measured at several points of time (before induction of anaesthesia
after induction but before start of surgery
after start of surgery
60min after start of surgery
after removal of the tumor tissue
after skin suture
during postoperative care in the recovery room) from blood Plasma of patients (30 patients, , Age >18years) undergoing General anesthesia for pancreatic cancer surgery.
Blood is drawn from venous cat
Sponsors
Universitätsklinikum Heidelberg Klinik für Anästhesiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: male; Age 18-70years; indication for whipple-surgery (pancreatic cancer surgery) for pancreatic cancer treatment; planned General anesthesia with or without epidural anaesthesia
Exclusion criteria
Exclusion criteria: female; incapacitated patients; dementia; psychotic disease; mental Retardation; neoadjuvant chemotherapy <3months before surgery; renal insufficiency (GFR <60ml/min); Diabetes type I or II with Need for drug therapy; autoimmune disorder (Lupus erythematodes, Sjögren Syndrome, Spondylitis alkylosans, CREST-Syndrome, sklerodermia, Morbus crohn, colitis ulcerosa, sarkoidose, goodpasture-syndrome, celiac disease, hashimoto-thyreoiditis, Morbus Basedow, autoimmune pancreatitis, multiple sklerosis, rheumatoid Arthritis); congenital immune disorders, iatrogene immune Suppression (Steroid therapy, Transplantation); blood transfusions <14days before surgery; therapy with immune modulating drugs (statines, Arginin, Coenzyme Q; Carnitin, Cyclosporin)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of perioperative, longitudinal metabolic changes on oncologic patients by quantitative analysis of metabolites (amino acids, carnitines, sugars, phospholipids, sphingolipids, fatty acids, bile acids, zytokines) via mass spectrometry using internal Standards in patients receiving General anesthesia during pancreatic cancer surgery (whipple's surgery) | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of possible anaesthesiologic factors that may influence metabolic changes. Generating further hypothesis for more detailed studies on the influence of anaesthesiologic procedures on cancer outcome. | — |
Countries
Germany
Contacts
Public ContactJohanna Ohnesorge
Universitätsklinikum Heidelberg Klinik für Anästhesiologie
Outcome results
None listed