healthy subjects
Conditions
Interventions
Group 1: T0:
written and informed consent
application Electrocardiography
preparation spiroergometry
T1 [Baseline]:
dynamic COMET measurement
respiratory gas analysis without exercise
measurement of
Sponsors
NWG Translational Septomics, Zentrum für Innovationskompetenz (ZIK) Septomics, Universitätklinikum Jena
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - written and informed consent - suitability for exercise test (Physical Activity Readiness Questionnaire)
Exclusion criteria
Exclusion criteria: - significant pre-existing cardiological or pulmonal disease as well as significant diseases of the musculoskeletal system -absolute contraindication for 5-aminolevulinic-acid-patch (required for COMET measurement: allergy to 5-aminolevulinic-acid-hydrocholride, acrylic adhesives, pigmented polyethylene or aluminized polyester, porphyria, skin disease which are caused or aggravated by sun light, increased sensitivity to sun light) - allergy to Nonivamid or Nicoboxil (ingredients Finalgon®) - pregnancy/breastfeeding - participation in another intervention study - previous participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim is the evaluation of the association between mitochondrial oxygen consumption (mitoVO2) and the spiroergometrically measured oxygen uptake (VO2) over the time points T1 – T4. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Evaluation of the association between mitochondrial oxygen tension (mitoPO2) and the spiroergometrically measured oxygen uptake (VO2) over the time points T1 – T4. - Evaluation of the association between mitochondrial oxygen delivery (mitoDO2) and the spiroergometrically measured oxygen uptake (VO2) over the time points T1 – T4. - Corresponding analyses for mitoPO2, mitoVO2 and mitoDO2 and other variables from spiroergometry. - Corresponding analyses for mitoPO2, mitoVO2 and mitoDO2 and variables from blood gas analysis. - Characterisation of the course of mitoPO2, mitoVO2 and mitoDO2 between T1 – T4. Additional research questions: - Exploratory analysis on the influence of the maximum oxygen intake (VO2:max) on baseline values (T1) of mitoPO2, mitoVO2 and mitoDO2 - Activity induced differences in mitoPO2, mitoVO2 and mitoDO2 between T1 and the last load level during spiroergometry | — |
Countries
Germany
Contacts
Public ContactPhilipp Baumbach
NWG Translational Septomics, Zentrum für Innovationskompetenz (ZKS) Septomics, Universitätsklinikum Jena
Outcome results
None listed