Postoperative pain Pain as diease
Conditions
Interventions
Group 1: Mini-incision injury model on the volar forearm as a surrogate for postoperative pain, taking skin and blood samples to determine the proteome
Sponsors
Universitätsklinik Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Male, Age 18-40, healthy, unremarkable QST report
Exclusion criteria
Exclusion criteria: Age over 40, pre-existing conditions (diabetes m .; cardiac pre-existing conditions, pruritus, skin diseases (arm), neurological diseases, medication intake, regular analgesic intake <3 days before experiment, conspicuous QST, chronic medication intake and pre-existing pain or chronic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of proteome (24 hours after incision) via mass spectroscopy from skin and blood samples for incision-related pain in a human surrogate model for postoperative pain. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Identification and correlation of candidate proteins that are more regulated in subjects with a large secondary hyperalgesia area after experimental incision than in subjects with a small secondary hyperalgesia area 2. What differences and similarities can be found between human and animal (mouse) in a comparable trauma in the proteome of skin and blood samples? | — |
Countries
Germany
Contacts
Public ContactEsther Pogatzki-Zahn
Universitätsklinik Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Outcome results
None listed