Different Exercise Interventions in the Treatment of Atrial Fibrillation – a prospective, randomized controlled trial.

Different Exercise Interventions in the Treatment of Atrial Fibrillation – a prospective, randomized controlled trial. - ExAfib

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00016637

Enrollment

Registered

2019-02-13

Start date

2019-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I48 I10

Interventions

Group 1: Control group: WHO recomendations, no additional training Group 2: 12 weeks resistance training 2x/week Group 3: 12 weeks classic low-intensity endurance training 2x/week Group 4: 12 weeks hi

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: symptomatic paroxysmal atrial fibrillation (EHRA = 2)

Exclusion criteria

Exclusion criteria: - 80 years of age - significant limitation to the exercise of the intervention-arms - BMI = 35 - participation in regular aerobic or resistance exercise training in the last 6 months - left ventricular ejection fraction < 40% during sinus rhythm - significant cardiac valve disease - implanted cardiac pacemaker or resynchronization therapy - coronary artery disease without complete revascularization - unstable Angina - uncontrolled arrhythmias causing unstable conditions - uncontrolled hypertension - uncontrolled Diabetes mellitus - prior pulmonary vein ablation - untreated secondary cause of AF (i.e. hyperthyroidism, etc.) - former high-performance athlete - any other contraindication or limitation to exercise

Design outcomes

Primary

Measure	Time frame
Safety and feasibility (adherence / adverse events)	—

Secondary

Measure	Time frame
- Physical fitness (VO2peak and strength) - burden of atrial fibrillation, defined as time in atrial fibrillation, measured by Holter-ECG - Muscle strength - Subjective burden of AF - Subjective quality of life (SF-36) - Major adverse cardiovascular events (MACE): Stroke, myocardial infarction, death from cardiovascular cause - Minor adverse events - Body composition - inflammatory markers (CRP, Interleukins) - Cardiac function (echocardiography incl. strain analysis; NTproBNP) - Blood pressure (24h) - Arterial stiffness (pulse wave analysis) - Heart rate (24h: min, max, average) - HRV (in sinus rhythm) - Muscle hypertrophy (viameter of Vastus lateralis)	—

Measure

Time frame

- Physical fitness (VO2peak and strength) - burden of atrial fibrillation, defined as time in atrial fibrillation, measured by Holter-ECG - Muscle strength - Subjective burden of AF - Subjective quality of life (SF-36) - Major adverse cardiovascular events (MACE): Stroke, myocardial infarction, death from cardiovascular cause - Minor adverse events - Body composition - inflammatory markers (CRP, Interleukins) - Cardiac function (echocardiography incl. strain analysis; NTproBNP) - Blood pressure (24h) - Arterial stiffness (pulse wave analysis) - Heart rate (24h: min, max, average) - HRV (in sinus rhythm) - Muscle hypertrophy (viameter of Vastus lateralis)

—

Countries

Germany

Contacts

Public ContactJonas Zacher

Deutsche Sporthochschule KölnInstitut für Kreislaufforschung und Sportmedizin

sportlich.im.takt@gmail.com+49 22149825152

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 17, 2026