Detection of brown adipose tissue via MRI and multispectral optoacustic tomography (MSOT): Correlation with thermogenic capacity after cold exposure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016629

Enrollment

Registered

2019-05-15

Start date

2019-03-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants

Interventions

Group 1: MRI is conducted on neck, adomen and pelvis, while heart rate and breathing are monitored. Depending on respiratory rate, measurements take 45-60 min. The MSOT device combines real-time imag

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Only participants of the FREECE study (DRKS00010489) will be recruited.

Exclusion criteria

Exclusion criteria: Pregnancy, high skin pigmentation, documented or suspected photo-allergy, erythropoietic protoporphyria, allergic contact dermatitis, or very sensitive skin open or infected wounds of observed regions strong claustrophobia implants or metal pieces in the body pacemaker aneurysm clips in the brain cochlear implants, tympanostomy tubes

Design outcomes

Primary

Measure	Time frame
Aim of this thesis is to correlate resting metabolic rate (assesed in DRKS00010489) with volume of brown adipose tissue. Measuring the proton density fat fraction via MRI (PDFF-MRI) of neck and pelvis will shed light on this. Furthermore, a multispectral optoacustic tomography (MSOT) will be facilitated and its results compared with forementioned results in order to investigate the sensitivity of MSOT for the quantification of brown adipose tissue at basal conditions. MSOT will be applied in the supraclavicular fossae and a gluteal region for reference.	—

Measure

Time frame

Aim of this thesis is to correlate resting metabolic rate (assesed in DRKS00010489) with volume of brown adipose tissue. Measuring the proton density fat fraction via MRI (PDFF-MRI) of neck and pelvis will shed light on this. Furthermore, a multispectral optoacustic tomography (MSOT) will be facilitated and its results compared with forementioned results in order to investigate the sensitivity of MSOT for the quantification of brown adipose tissue at basal conditions. MSOT will be applied in the supraclavicular fossae and a gluteal region for reference.

—

Secondary

Measure	Time frame
Secondary outcome is the association of these results with the data received by the FREECE study	—

Countries

Germany

Contacts

Public ContactClaudine Seeliger

Else Kröner-Fresenius-Zentrum für Ernährungsmedizin der TU München

claudine.seeliger@tum.de08161712006

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026