Evaluation of a novel test to detect subtle cognitive deficits in relapsing-remitting Multiple Sclerosis

Evaluation of a novel test to detect subtle cognitive deficits in relapsing-remitting Multiple Sclerosis - EARLY COGDYS IN MS 001

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00016600

Enrollment

210

Registered

2019-02-12

Start date

2019-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G35

Interventions

Group 1: CIS, recently diagnosed MS patients. Cross-sectional procedure: neurological examination, OCT, neuropsychological examination, blood sampling, action cascading task with EEG recording, DTI Gr

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. CIS or newly diagnosed MS patients (McDonald criteria). Diagnosis 6 months, no relapses within 6 months. 3. SPMS patients. Start of treatment < 20 years, EDSS < 6.5 and no relapses within 6 months. Age between 18 and 50 years

Exclusion criteria

Exclusion criteria: Other neurological pre-existing conditions other than MS - Psychiatric disorders - Occurrence of learning disorders, severe head injuries, substance abuse, epilepsy - Corticosteroid intake within 4 weeks before study participation - Non-correctable hearing and visual impairments

Design outcomes

Primary

Measure	Time frame
Reaction times (RTs) and error rates in the action cascading paradigm. EEG measures derived from EEG recordings during the administration of the action cascading paradigm.	—

Secondary

Measure	Time frame
Integration of the EEG and behavioral data with the MRI data.	—

Countries

Germany

Contacts

Public ContactMoritz Mückschel

Zentrum für klinische Neurowissenschaften

MS.Kognition@ukdd.de+493514584073

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026