F90
Conditions
Interventions
Group 1: This is a non-interventional study (EEG, neuropsychological testing, interview), which is independent of the clinical drug treatment with methylphenidate.
Amendment 4 to DRKS00014922
"Pathop
no medication)
Sponsors
Klinik für Psychiatrie und Psychotherapie der Uniklinik Köln
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patients: (1) Sufficient knowledge of the German language (2) Written informed consent (3) ADHD diagnosis according to ICD-10 (4) Clinically prescribed treatment with methylphenidate for at least 6 months (5) Stable psychotropic medication (apart from ADHD medication) for at least 4 weeks control group: (1) Sufficient knowledge of the German language (2) Written informed consent
Exclusion criteria
Exclusion criteria: Patients: (1) Known neurological disorders affecting the brain, including condition after craniocerebral trauma with unconsciousness lasting for more than 5 minutes (2) Any diagnosis including Autism, Morbus Parkinson, Schizophrenia or Obsessive Compulsive Disorder (3) Harmful substance abuse according to ICD-10 (4) Motor hyperactivity at the time of EEG measurement (5) Known IQ < 70 (6) premature birth < 32 wks (7) use of antidepressants (except for SSRI) Control group: (1) Known neurological disorders affecting the brain, including condition after craniocerebral trauma with unconsciousness lasting for more than 5 minutes (2) Any diagnosis including ADHD, Autism, Depression, Morbus Parkinson, Schizophrenia or Obsessive Compulsive Disorder (3) Harmful substance abuse according to ICD-10 (4) Motor hyperactivity at the time of EEG measurement (5) Known IQ < 70 (6) premature birth < 32 wks (7) use of antidepressants (except for SSRI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence for specific changes in neuronal activity measured by means of EEG, in relation to drug-related effects over the course of the day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship between EEG parameters, drug-related effects over course of time, neuropsychological testing, level of cognitive performance, results of kidney and liver blood parameters, and interviews regarding the patients' current condition (ADHS-E, Wender Utah Rating Scale short form (WURS-K), Wender-Reimherr-Interview (WRI-V)). | — |
Countries
Germany
Contacts
Public ContactRalf Müller
Klinik für Psychiatrie und Psychotherapie der Uniklinik Köln
Outcome results
None listed