F10.1 F10.2
Conditions
Interventions
Group 1: In work package 1, n=75 patients with moderate alcohol use disorder and n=75 healthy control subjects are each examined once using behavioral paradigms and EEG. The paradigms are presented vi
Sponsors
Kinder- und Jugendpsychiatrie am Univeristätsklinikum Carl Gustav Carus Dresden
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Men and women aged 20-40 years; Alcohol-use disorder according to 4-5 diagnostic DSM-5 criteria for subjects with moderate AUD (Alcohol Use Disorder); Ability to provide fully informed consent and to use self-rating scales; Sufficient understanding of the German language
Exclusion criteria
Exclusion criteria: Lifetime history of DSM-5 bipolar, psychotic disorder, or substance dependence other than alcohol / nicotine; Current substance use other than nicotine and alcohol as evinced by positive urine test; Current threshold DSM-5 diagnosis of any of the following disorders: current (hypo)manic episode, major depressive disorder, generalized anxiety disorder, PTSD, borderline personality disorder, or obsessive compulsive disorder; History of severe head trauma or other severe central neurological disorder (dementia, Parkinson’s disease, multiple sclerosis, epilepsia); Pregnancy or nursing infants; Metal implants in body or head, as the beamforming source localization in WP1 and the cTBS in WP2 will be based on structural MR images / neuro-navigated; Current use of medications or drugs known to interact with the CNS within at least four half-lives post last intake
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| On each study appointment, the behavioural performance will be measured in three different experimental paradigms that assess aspects of action control and automatisms. The behavioural data (number of correct/incorrect responses as well as response times) will be collected with the help of the software “Presentation” (Neurobehavioral Systems Inc.). | — |
Secondary
| Measure | Time frame |
|---|---|
| On each study appointment, EEG correlates of the observed behavioral differences will be measured during the three different experimental paradigms using the software “BrainVision Recorder” (Brain Products GmbH). | — |
Countries
Germany
Contacts
Public ContactClaudia Seifert
Kinder- und Jugendpsychiatrie am Universitätsklinikum Carl Gustav Carus Dresden
Outcome results
None listed